St. Anthony's College, Shillong, is an educational institution of the Catholic Church, belonging to and managed by the Salesians of Don Bosco Educational Society, registered under the Societies Registration Act of 1890:No SR/SAC-227/91 of 1991. Guided by the religious and educational philosophy of St. John Bosco, the College founded in 1934, brings college education within the reach of the common man and woman. Ever since the college has been in the vanguard of higher educaiton in North-East India and has been recognised as one among the leading colleges in the country by the University Grants Commission.

Listed below are the names of the Principals of the College starting from 1934. Each in his own ability and caliber has further developed and perfected St.Anthony's College.